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Padcev not actual patients Padcev not actual patients




Additional resources

There are many groups and organizations dedicated to providing help for you and your loved ones.
The following may be able to help.

Astellas and Seattle Genetics are not affiliated with and do not endorse any of the listed
organizations. The information provided is for informational purposes only and is not meant to
replace the advice of a healthcare professional.

These patient support groups are included as a reference for patients and caregivers. Their
inclusion does not imply endorsement from the individual patient support groups listed.

Tips for caregivers

The role you play as a caregiver is very important. However, it is also important to look after your own health and wellness. Below are some tips to help you look after your own well-being while supporting your family member or friend throughout their treatment.

Padcev not actual patients and caregivers
Padcev not actual patients and caregivers

Tips for caregivers

The role you play as a caregiver is very important. However, it is also important to look after your own health and wellness. Below are some tips to help you look after your own well-being while supporting your family member or friend throughout their treatment.

The role you play as a caregiver is very important. However, it is also important to look after your own health and wellness. Below are some tips to help you look after your own well-being while supporting your family member or friend throughout their treatment.

Padcev Doctor Discussion Guide Icon

Help the person you care for keep track of how they're feeling

Write down lists of questions as they come up and keep track of any side effects the person you care for experiences. The PADCEV Discussion Guide and Symptom Tracker can help. Download a copy.

Padcev Ask for Help Icon

It's OK to ask for help

As a caregiver, you may feel like you need to take care of everything, but sometimes you may need support, too. People may want to help you and the person you care for, but they may not know how. Speak up and ask friends and family members to help out with tasks when you need help.

Padcev Make Time for Yourself Icon

Make time for yourself and other relationships

Take the time to do something you enjoy. It’s also helpful to spend time with other people in your life who are important to you.

Padcev Dont Forget About Yourself Icon

Don't forget about yourself

Being a caregiver will keep you busy. Remember to schedule appointments with your doctor to talk about ways you can stay healthy, such as eating well and getting enough sleep. Don't be afraid to ask friends and loved ones for help.




Frequently Asked Questions

Below is a list of frequently asked questions. Please note, any and all questions regarding PADCEV™ should be discussed with your doctor or nurse.

Padcev not actual patients
Padcev not actual patients

Frequently Asked Questions

Below is a list of frequently asked questions. Please note, any and all questions regarding PADCEV™ should be discussed with your doctor or nurse.

Below is a list of frequently asked questions. Please note, any and all questions regarding PADCEV™ should be discussed with your doctor or nurse.

  • Is PADCEV right for me?

      Your doctor may prescribe PADCEV if you’re an adult with bladder cancer or a cancer of the urinary tract (renal pelvis, ureter, or urethra) that has spread or cannot be removed by surgery. PADCEV can be used if you have received an immunotherapy drug and also received a chemotherapy-containing platinum medicine. It is not known if PADCEV is safe and effective in children. Learn more >

  • How is PADCEV different from other treatments I have already received?

      PADCEV works differently from the chemotherapy or immunotherapy you may have had before because PADCEV is an antibody-drug conjugate (ADC). PADCEV works by delivering medicine directly to cancer cells, but can also harm normal cells and cause side effects. Learn more >

  • What are the potential serious side effects of PADCEV?

      During treatment with PADCEV, serious side effects may occur and should be treated by your doctor or nurse as early as possible. Serious side effects occurred in 46% of patients treated with PADCEV. The most common serious side effects (≥3%) were urinary tract infection (6%), bacterial skin infection (cellulitis) (5%), fever & low white blood cell count (febrile neutropenia) (4%), diarrhea (4%), blood infection (sepsis) (3%), kidney damage (acute kidney injury) (3%), shortness of breath (dyspnea) (3%), and rash (3%).

      Fatal side effects occurred in 3.2% of patients, including lung problems (acute respiratory failure), lung infection (aspiration pneumonia), heart problems (cardiac disorder), and blood infection (sepsis) (each 0.8%). Learn more >

  • What should I do if I experience a side effect while taking PADCEV?

      Side effects may occur with PADCEV. You and your caregiver(s) should always talk to your doctor or nurse right away about any side effects you experience, or if these get worse. Learn more >

      You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch

  • How will I receive PADCEV?

      You will receive PADCEV by intravenous (IV) infusion. This will last for 30 minutes. Learn more >

  • How long will I receive PADCEV?

      You will receive PADCEV over a 28-day cycle. Within each cycle, you will receive PADCEV on days 1, 8, and 15.

      Your doctor will determine how many treatment cycles you need. Learn more >

  • Is there support available to help me access PADCEV?

      Yes, PADCEV Support Solutions offers access and reimbursement support to help patients like you, who have been prescribed PADCEV™, access their medication. Call PADCEV Support Solutions at 1-888-402-0627 Monday-Friday, 8:30 AM to 8:00 PM ET if you have any questions or need assistance.



IMPORTANT SAFETY INFORMATION

Before receiving PADCEV, tell your healthcare provider about all of your medical conditions, including if you:

are currently experiencing numbness or tingling in your hands or feet

have a history of high blood sugar or diabetes

are pregnant or plan to become pregnant. PADCEV can harm your unborn baby. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with PADCEV

are breastfeeding or plan to breastfeed. It is not known if PADCEV passes into your breast milk. Do not breastfeed during treatment and for at least 3 weeks after the last dose of PADCEV

Females who are able to become
pregnant:

Your healthcare provider should do a pregnancy test before you start treatment with PADCEV.

You should use an effective method of birth control during your treatment and for at least 2 months after the last dose of PADCEV.

Males with a female sexual partner
who is able to become pregnant:

If your female partner is pregnant, PADCEV can harm the unborn baby.

You should use an effective method of birth control during your treatment and for at least 4 months after the last dose of PADCEV.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

How will you receive PADCEV?

PADCEV will be given to you by intravenous (IV) infusion into your vein over 30 minutes.

You will receive your PADCEV over periods of time called cycles.

- Each PADCEV cycle is 28 days.

- You will receive PADCEV on days 1, 8 and 15 of every cycle.

Your healthcare provider will decide how many treatment cycles you need.

Your healthcare provider may do blood tests regularly during treatment with PADCEV.

What are the possible side effects of PADCEV?
PADCEV may cause serious side effects including:

High Blood Sugar (hyperglycemia). You can develop high blood sugar during treatment with PADCEV. Tell your healthcare provider right away if you have any symptoms of high blood sugar, including: frequent urination, increased thirst, blurred vision, confusion, it becomes harder to control your blood sugar, drowsiness, loss of appetite, fruity smell on your breath, nausea, vomiting, or stomach pain.

Peripheral neuropathy. While receiving PADCEV you may experience nerve problems called peripheral neuropathy. Tell your healthcare provider right away if you experience numbness or tingling in your hands or feet, or muscle weakness.

Eye problems. You can develop certain eye problems while receiving PADCEV. Tell your healthcare provider right away if you have dry eyes or blurred vision.

Skin reactions. Rashes and severe skin reactions can happen while receiving PADCEV. Tell your healthcare provider right away if you get a rash or a skin reaction that continues to get worse.

Leakage of PADCEV out of your vein into the tissues around your infusion site (extravasation). If PADCEV leaks from the injection site or the vein into the nearby skin and tissues, it could cause an infusion site reaction. These reactions can happen right after you receive an infusion, but sometimes may happen days after your infusion. Tell your healthcare provider or get medical help right away if you notice any redness, swelling, itching, or discomfort at the infusion site.

The most common side effects of PADCEV
include:

numbness or tingling in your hands or feet, or muscle weakness

fatigue

decreased appetite

rash

hair loss

nausea

diarrhea

change in sense of taste

dry eyes

dry skin

If you have certain side effects, your healthcare provider may decrease your dose or stop your treatment with PADCEV for a period of time (temporarily) or completely.

PADCEV may cause fertility problems in males, which may affect the ability to father children. Talk to your healthcare provider if you have concerns about fertility.

These are not all the possible side effects of PADCEV.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please click here for full Prescribing Information.



WHAT IS PADCEV™?

PADCEV (enfortumab vedotin-ejfv) is a prescription medicine used to treat adults with bladder cancer and cancers of the urinary tract (renal pelvis, ureter or urethra) that has spread or cannot be removed by surgery. PADCEV may be used if you have received an immunotherapy medicine and also received a chemotherapy-containing platinum medicine. It is not known if PADCEV is safe and effective in children.

PADCEV was FDA-approved based on a clinical study that measured how many patients had a tumor response. There is another study with PADCEV to confirm the clinical benefit.

Please click here for full Prescribing Information.



IMPORTANT SAFETY INFORMATION

Before receiving PADCEV, tell your healthcare provider about all of your medical conditions, including if you:

are currently experiencing numbness or tingling in your hands or feet

have a history of high blood sugar or diabetes

are pregnant or plan to become pregnant. PADCEV can harm your unborn baby. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with PADCEV

are breastfeeding or plan to breastfeed. It is not known if PADCEV passes into your breast milk. Do not breastfeed during treatment and for at least 3 weeks after the last dose of PADCEV

Females who are able to become
pregnant:

Your healthcare provider should do a pregnancy test before you start treatment with PADCEV.

You should use an effective method of birth control during your treatment and for at least 2 months after the last dose of PADCEV.

Males with a female sexual partner
who is able to become pregnant:

If your female partner is pregnant, PADCEV can harm the unborn baby.

You should use an effective method of birth control during your treatment and for at least 4 months after the last dose of PADCEV.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

How will you receive PADCEV?

PADCEV will be given to you by intravenous (IV) infusion into your vein over 30 minutes.

You will receive your PADCEV over periods of time called cycles.

- Each PADCEV cycle is 28 days.

- You will receive PADCEV on days 1, 8 and 15 of every cycle.

Your healthcare provider will decide how many treatment cycles you need.

Your healthcare provider may do blood tests regularly during treatment with PADCEV.

What are the possible side effects of PADCEV?
PADCEV may cause serious side effects including:

High Blood Sugar (hyperglycemia). You can develop high blood sugar during treatment with PADCEV. Tell your healthcare provider right away if you have any symptoms of high blood sugar, including: frequent urination, increased thirst, blurred vision, confusion, it becomes harder to control your blood sugar, drowsiness, loss of appetite, fruity smell on your breath, nausea, vomiting, or stomach pain.

Peripheral neuropathy. While receiving PADCEV you may experience nerve problems called peripheral neuropathy. Tell your healthcare provider right away if you experience numbness or tingling in your hands or feet, or muscle weakness.

Eye problems. You can develop certain eye problems while receiving PADCEV. Tell your healthcare provider right away if you have dry eyes or blurred vision.

Skin reactions. Rashes and severe skin reactions can happen while receiving PADCEV. Tell your healthcare provider right away if you get a rash or a skin reaction that continues to get worse.

Leakage of PADCEV out of your vein into the tissues around your infusion site (extravasation). If PADCEV leaks from the injection site or the vein into the nearby skin and tissues, it could cause an infusion site reaction. These reactions can happen right after you receive an infusion, but sometimes may happen days after your infusion. Tell your healthcare provider or get medical help right away if you notice any redness, swelling, itching, or discomfort at the infusion site.

The most common side effects of PADCEV
include:

numbness or tingling in your hands or feet, or muscle weakness

fatigue

decreased appetite

rash

hair loss

nausea

diarrhea

change in sense of taste

dry eyes

dry skin

If you have certain side effects, your healthcare provider may decrease your dose or stop your treatment with PADCEV for a period of time (temporarily) or completely.

PADCEV may cause fertility problems in males, which may affect the ability to father children. Talk to your healthcare provider if you have concerns about fertility.

These are not all the possible side effects of PADCEV.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please click here for full Prescribing Information.



WHAT IS PADCEV™?

PADCEV (enfortumab vedotin-ejfv) is a prescription medicine used to treat adults with bladder cancer and cancers of the urinary tract (renal pelvis, ureter or urethra) that has spread or cannot be removed by surgery. PADCEV may be used if you have received an immunotherapy medicine and also received a chemotherapy-containing platinum medicine. It is not known if PADCEV is safe and effective in children.

PADCEV was FDA-approved based on a clinical study that measured how many patients had a tumor response. There is another study with PADCEV to confirm the clinical benefit.

Please click here for full Prescribing Information.



IMPORTANT SAFETY INFORMATION

Before receiving PADCEV, tell your healthcare provider about all of your medical conditions, including if you:

are currently experiencing numbness or tingling in your hands or feet

have a history of high blood sugar or diabetes

are pregnant or plan to become pregnant. PADCEV can harm your unborn baby. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with PADCEV

are breastfeeding or plan to breastfeed. It is not known if PADCEV passes into your breast milk. Do not breastfeed during treatment and for at least 3 weeks after the last dose of PADCEV

Females who are able to become
pregnant:

Your healthcare provider should do a pregnancy test before you start treatment with PADCEV.

You should use an effective method of birth control during your treatment and for at least 2 months after the last dose of PADCEV.

Males with a female sexual partner
who is able to become pregnant:

If your female partner is pregnant, PADCEV can harm the unborn baby.

You should use an effective method of birth control during your treatment and for at least 4 months after the last dose of PADCEV.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

How will you receive PADCEV?

PADCEV will be given to you by intravenous (IV) infusion into your vein over 30 minutes.

You will receive your PADCEV over periods of time called cycles.

- Each PADCEV cycle is 28 days.

- You will receive PADCEV on days 1, 8 and 15 of every cycle.

Your healthcare provider will decide how many treatment cycles you need.

Your healthcare provider may do blood tests regularly during treatment with PADCEV.

What are the possible side effects of PADCEV?
PADCEV may cause serious side effects including:

High Blood Sugar (hyperglycemia). You can develop high blood sugar during treatment with PADCEV. Tell your healthcare provider right away if you have any symptoms of high blood sugar, including: frequent urination, increased thirst, blurred vision, confusion, it becomes harder to control your blood sugar, drowsiness, loss of appetite, fruity smell on your breath, nausea, vomiting, or stomach pain.

Peripheral neuropathy. While receiving PADCEV you may experience nerve problems called peripheral neuropathy. Tell your healthcare provider right away if you experience numbness or tingling in your hands or feet, or muscle weakness.

Eye problems. You can develop certain eye problems while receiving PADCEV. Tell your healthcare provider right away if you have dry eyes or blurred vision.

Skin reactions. Rashes and severe skin reactions can happen while receiving PADCEV. Tell your healthcare provider right away if you get a rash or a skin reaction that continues to get worse.

Leakage of PADCEV out of your vein into the tissues around your infusion site (extravasation). If PADCEV leaks from the injection site or the vein into the nearby skin and tissues, it could cause an infusion site reaction. These reactions can happen right after you receive an infusion, but sometimes may happen days after your infusion. Tell your healthcare provider or get medical help right away if you notice any redness, swelling, itching, or discomfort at the infusion site.

The most common side effects of PADCEV
include:

numbness or tingling in your hands or feet, or muscle weakness

fatigue

decreased appetite

rash

hair loss

nausea

diarrhea

change in sense of taste

dry eyes

dry skin

If you have certain side effects, your healthcare provider may decrease your dose or stop your treatment with PADCEV for a period of time (temporarily) or completely.

PADCEV may cause fertility problems in males, which may affect the ability to father children. Talk to your healthcare provider if you have concerns about fertility.

These are not all the possible side effects of PADCEV.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please click here for full Prescribing Information.



WHAT IS PADCEV™?

PADCEV (enfortumab vedotin-ejfv) is a prescription medicine used to treat adults with bladder cancer and cancers of the urinary tract (renal pelvis, ureter or urethra) that has spread or cannot be removed by surgery. PADCEV may be used if you have received an immunotherapy medicine and also received a chemotherapy-containing platinum medicine. It is not known if PADCEV is safe and effective in children.

PADCEV was FDA-approved based on a clinical study that measured how many patients had a tumor response. There is another study with PADCEV to confirm the clinical benefit.

Please click here for full Prescribing Information.

© 2020 Astellas Pharma US, Inc. and Seattle Genetics, Inc. All rights reserved. 81-0047-PM 02/20
PADCEV and the PADCEV logo are trademarks jointly owned by Agensys, Inc. and Seattle Genetics, Inc.
Astellas and the flying star logo are registered trademarks of Astellas Pharma Inc.
Seattle Genetics and the Seattle Genetics logo are registered trademarks of Seattle Genetics, Inc.


© 2020 Astellas Pharma US, Inc. and Seattle Genetics, Inc. All rights reserved. 81-0047-PM 02/20
PADCEV and the PADCEV logo are trademarks jointly owned by Agensys, Inc. and Seattle Genetics, Inc.
Astellas and the flying star logo are registered trademarks of Astellas Pharma Inc.
Seattle Genetics and the Seattle Genetics logo are registered trademarks of Seattle Genetics, Inc.

© 2020 Astellas Pharma US, Inc. and Seattle Genetics, Inc. All rights reserved. 81-0047-PM 02/20
PADCEV and the PADCEV logo are trademarks jointly owned by Agensys, Inc. and Seattle Genetics, Inc.
Astellas and the flying star logo are registered trademarks of Astellas Pharma Inc.
Seattle Genetics and the Seattle Genetics logo are registered trademarks of Seattle Genetics, Inc.


© 2020 Astellas Pharma US, Inc. and Seattle Genetics, Inc. All rights reserved. 81-0047-PM 02/20
PADCEV and the PADCEV logo are trademarks jointly owned by Agensys, Inc. and Seattle Genetics, Inc.
Astellas and the flying star logo are registered trademarks of Astellas Pharma Inc.
Seattle Genetics and the Seattle Genetics logo are registered trademarks of Seattle Genetics, Inc.