What is locally advanced or metastatic urothelial (bladder) cancer?

Urothelial (bladder) cancer begins in the lining of the organs in the urinary bladder system. When the cancer spreads to nearby areas, it is called locally advanced cancer. If it has spread to distant parts of the body, like the lymph nodes or other organs, it is called metastatic cancer.

Padcev not actual patients Padcev not actual patients

Urothelial (bladder) cancer begins in the lining of the organs in the urinary bladder system. When the cancer spreads to nearby areas, it is called locally advanced cancer. If it has spread to distant parts of the body, like the lymph nodes or other organs, it is called metastatic cancer.



How cancer spreads from the bladder:

Cancer cells spreading from bladder through muscle, connective tissue, and fat
Padcev Information Icon

Before starting treatment with PADCEV™, talk to your doctor about all your medical conditions and any medicines you are taking including prescription and over-the-counter medicines, vitamins, and herbal supplements.



IMPORTANT SAFETY INFORMATION

Before receiving PADCEV, tell your healthcare provider about all of your medical conditions, including if you:

are currently experiencing numbness or tingling in your hands or feet

have a history of high blood sugar or diabetes

are pregnant or plan to become pregnant. PADCEV can harm your unborn baby. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with PADCEV

are breastfeeding or plan to breastfeed. It is not known if PADCEV passes into your breast milk. Do not breastfeed during treatment and for at least 3 weeks after the last dose of PADCEV

Females who are able to become
pregnant:

Your healthcare provider should do a pregnancy test before you start treatment with PADCEV.

You should use an effective method of birth control during your treatment and for at least 2 months after the last dose of PADCEV.

Males with a female sexual partner
who is able to become pregnant:

If your female partner is pregnant, PADCEV can harm the unborn baby.

You should use an effective method of birth control during your treatment and for at least 4 months after the last dose of PADCEV.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

How will you receive PADCEV?

PADCEV will be given to you by intravenous (IV) infusion into your vein over 30 minutes.

You will receive your PADCEV over periods of time called cycles.

- Each PADCEV cycle is 28 days.

- You will receive PADCEV on days 1, 8 and 15 of every cycle.

Your healthcare provider will decide how many treatment cycles you need.

Your healthcare provider may do blood tests regularly during treatment with PADCEV.

What are the possible side effects of PADCEV?
PADCEV may cause serious side effects including:

High Blood Sugar (hyperglycemia). You can develop high blood sugar during treatment with PADCEV. Tell your healthcare provider right away if you have any symptoms of high blood sugar, including: frequent urination, increased thirst, blurred vision, confusion, it becomes harder to control your blood sugar, drowsiness, loss of appetite, fruity smell on your breath, nausea, vomiting, or stomach pain.

Peripheral neuropathy. While receiving PADCEV you may experience nerve problems called peripheral neuropathy. Tell your healthcare provider right away if you experience numbness or tingling in your hands or feet, or muscle weakness.

Eye problems. You can develop certain eye problems while receiving PADCEV. Tell your healthcare provider right away if you have dry eyes or blurred vision.

Skin reactions. Rashes and severe skin reactions can happen while receiving PADCEV. Tell your healthcare provider right away if you get a rash or a skin reaction that continues to get worse.

Leakage of PADCEV out of your vein into the tissues around your infusion site (extravasation). If PADCEV leaks from the injection site or the vein into the nearby skin and tissues, it could cause an infusion site reaction. These reactions can happen right after you receive an infusion, but sometimes may happen days after your infusion. Tell your healthcare provider or get medical help right away if you notice any redness, swelling, itching, or discomfort at the infusion site.

The most common side effects of PADCEV
include:

numbness or tingling in your hands or feet, or muscle weakness

fatigue

decreased appetite

rash

hair loss

nausea

diarrhea

change in sense of taste

dry eyes

dry skin

If you have certain side effects, your healthcare provider may decrease your dose or stop your treatment with PADCEV for a period of time (temporarily) or completely.

PADCEV may cause fertility problems in males, which may affect the ability to father children. Talk to your healthcare provider if you have concerns about fertility.

These are not all the possible side effects of PADCEV.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please click here for full Prescribing Information.



WHAT IS PADCEV™?

PADCEV (enfortumab vedotin-ejfv) is a prescription medicine used to treat adults with bladder cancer and cancers of the urinary tract (renal pelvis, ureter or urethra) that has spread or cannot be removed by surgery. PADCEV may be used if you have received an immunotherapy medicine and also received a chemotherapy-containing platinum medicine. It is not known if PADCEV is safe and effective in children.

PADCEV was FDA-approved based on a clinical study that measured how many patients had a tumor response. There is another study with PADCEV to confirm the clinical benefit.

Please click here for full Prescribing Information.



IMPORTANT SAFETY INFORMATION

Before receiving PADCEV, tell your healthcare provider about all of your medical conditions, including if you:

are currently experiencing numbness or tingling in your hands or feet

have a history of high blood sugar or diabetes

are pregnant or plan to become pregnant. PADCEV can harm your unborn baby. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with PADCEV

are breastfeeding or plan to breastfeed. It is not known if PADCEV passes into your breast milk. Do not breastfeed during treatment and for at least 3 weeks after the last dose of PADCEV

Females who are able to become
pregnant:

Your healthcare provider should do a pregnancy test before you start treatment with PADCEV.

You should use an effective method of birth control during your treatment and for at least 2 months after the last dose of PADCEV.

Males with a female sexual partner
who is able to become pregnant:

If your female partner is pregnant, PADCEV can harm the unborn baby.

You should use an effective method of birth control during your treatment and for at least 4 months after the last dose of PADCEV.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

How will you receive PADCEV?

PADCEV will be given to you by intravenous (IV) infusion into your vein over 30 minutes.

You will receive your PADCEV over periods of time called cycles.

- Each PADCEV cycle is 28 days.

- You will receive PADCEV on days 1, 8 and 15 of every cycle.

Your healthcare provider will decide how many treatment cycles you need.

Your healthcare provider may do blood tests regularly during treatment with PADCEV.

What are the possible side effects of PADCEV?
PADCEV may cause serious side effects including:

High Blood Sugar (hyperglycemia). You can develop high blood sugar during treatment with PADCEV. Tell your healthcare provider right away if you have any symptoms of high blood sugar, including: frequent urination, increased thirst, blurred vision, confusion, it becomes harder to control your blood sugar, drowsiness, loss of appetite, fruity smell on your breath, nausea, vomiting, or stomach pain.

Peripheral neuropathy. While receiving PADCEV you may experience nerve problems called peripheral neuropathy. Tell your healthcare provider right away if you experience numbness or tingling in your hands or feet, or muscle weakness.

Eye problems. You can develop certain eye problems while receiving PADCEV. Tell your healthcare provider right away if you have dry eyes or blurred vision.

Skin reactions. Rashes and severe skin reactions can happen while receiving PADCEV. Tell your healthcare provider right away if you get a rash or a skin reaction that continues to get worse.

Leakage of PADCEV out of your vein into the tissues around your infusion site (extravasation). If PADCEV leaks from the injection site or the vein into the nearby skin and tissues, it could cause an infusion site reaction. These reactions can happen right after you receive an infusion, but sometimes may happen days after your infusion. Tell your healthcare provider or get medical help right away if you notice any redness, swelling, itching, or discomfort at the infusion site.

The most common side effects of PADCEV
include:

numbness or tingling in your hands or feet, or muscle weakness

fatigue

decreased appetite

rash

hair loss

nausea

diarrhea

change in sense of taste

dry eyes

dry skin

If you have certain side effects, your healthcare provider may decrease your dose or stop your treatment with PADCEV for a period of time (temporarily) or completely.

PADCEV may cause fertility problems in males, which may affect the ability to father children. Talk to your healthcare provider if you have concerns about fertility.

These are not all the possible side effects of PADCEV.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please click here for full Prescribing Information.



WHAT IS PADCEV™?

PADCEV (enfortumab vedotin-ejfv) is a prescription medicine used to treat adults with bladder cancer and cancers of the urinary tract (renal pelvis, ureter or urethra) that has spread or cannot be removed by surgery. PADCEV may be used if you have received an immunotherapy medicine and also received a chemotherapy-containing platinum medicine. It is not known if PADCEV is safe and effective in children.

PADCEV was FDA-approved based on a clinical study that measured how many patients had a tumor response. There is another study with PADCEV to confirm the clinical benefit.

Please click here for full Prescribing Information.



IMPORTANT SAFETY INFORMATION

Before receiving PADCEV, tell your healthcare provider about all of your medical conditions, including if you:

are currently experiencing numbness or tingling in your hands or feet

have a history of high blood sugar or diabetes

are pregnant or plan to become pregnant. PADCEV can harm your unborn baby. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with PADCEV

are breastfeeding or plan to breastfeed. It is not known if PADCEV passes into your breast milk. Do not breastfeed during treatment and for at least 3 weeks after the last dose of PADCEV

Females who are able to become
pregnant:

Your healthcare provider should do a pregnancy test before you start treatment with PADCEV.

You should use an effective method of birth control during your treatment and for at least 2 months after the last dose of PADCEV.

Males with a female sexual partner
who is able to become pregnant:

If your female partner is pregnant, PADCEV can harm the unborn baby.

You should use an effective method of birth control during your treatment and for at least 4 months after the last dose of PADCEV.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

How will you receive PADCEV?

PADCEV will be given to you by intravenous (IV) infusion into your vein over 30 minutes.

You will receive your PADCEV over periods of time called cycles.

- Each PADCEV cycle is 28 days.

- You will receive PADCEV on days 1, 8 and 15 of every cycle.

Your healthcare provider will decide how many treatment cycles you need.

Your healthcare provider may do blood tests regularly during treatment with PADCEV.

What are the possible side effects of PADCEV?
PADCEV may cause serious side effects including:

High Blood Sugar (hyperglycemia). You can develop high blood sugar during treatment with PADCEV. Tell your healthcare provider right away if you have any symptoms of high blood sugar, including: frequent urination, increased thirst, blurred vision, confusion, it becomes harder to control your blood sugar, drowsiness, loss of appetite, fruity smell on your breath, nausea, vomiting, or stomach pain.

Peripheral neuropathy. While receiving PADCEV you may experience nerve problems called peripheral neuropathy. Tell your healthcare provider right away if you experience numbness or tingling in your hands or feet, or muscle weakness.

Eye problems. You can develop certain eye problems while receiving PADCEV. Tell your healthcare provider right away if you have dry eyes or blurred vision.

Skin reactions. Rashes and severe skin reactions can happen while receiving PADCEV. Tell your healthcare provider right away if you get a rash or a skin reaction that continues to get worse.

Leakage of PADCEV out of your vein into the tissues around your infusion site (extravasation). If PADCEV leaks from the injection site or the vein into the nearby skin and tissues, it could cause an infusion site reaction. These reactions can happen right after you receive an infusion, but sometimes may happen days after your infusion. Tell your healthcare provider or get medical help right away if you notice any redness, swelling, itching, or discomfort at the infusion site.

The most common side effects of PADCEV
include:

numbness or tingling in your hands or feet, or muscle weakness

fatigue

decreased appetite

rash

hair loss

nausea

diarrhea

change in sense of taste

dry eyes

dry skin

If you have certain side effects, your healthcare provider may decrease your dose or stop your treatment with PADCEV for a period of time (temporarily) or completely.

PADCEV may cause fertility problems in males, which may affect the ability to father children. Talk to your healthcare provider if you have concerns about fertility.

These are not all the possible side effects of PADCEV.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Please click here for full Prescribing Information.



WHAT IS PADCEV™?

PADCEV (enfortumab vedotin-ejfv) is a prescription medicine used to treat adults with bladder cancer and cancers of the urinary tract (renal pelvis, ureter or urethra) that has spread or cannot be removed by surgery. PADCEV may be used if you have received an immunotherapy medicine and also received a chemotherapy-containing platinum medicine. It is not known if PADCEV is safe and effective in children.

PADCEV was FDA-approved based on a clinical study that measured how many patients had a tumor response. There is another study with PADCEV to confirm the clinical benefit.

Please click here for full Prescribing Information.

© 2020 Astellas Pharma US, Inc. and Seattle Genetics, Inc. All rights reserved. 81-0047-PM 02/20
PADCEV and the PADCEV logo are trademarks jointly owned by Agensys, Inc. and Seattle Genetics, Inc.
Astellas and the flying star logo are registered trademarks of Astellas Pharma Inc.
Seattle Genetics and the Seattle Genetics logo are registered trademarks of Seattle Genetics, Inc.


© 2020 Astellas Pharma US, Inc. and Seattle Genetics, Inc. All rights reserved. 081-0199-PM 07/20
PADCEV and the PADCEV logo are trademarks jointly owned by Agensys, Inc. and Seattle Genetics, Inc.
Astellas and the flying star logo are registered trademarks of Astellas Pharma Inc.
Seattle Genetics and the Seattle Genetics logo are registered trademarks of Seattle Genetics, Inc.

© 2020 Astellas Pharma US, Inc. and Seattle Genetics, Inc. All rights reserved. 81-0047-PM 02/20
PADCEV and the PADCEV logo are trademarks jointly owned by Agensys, Inc. and Seattle Genetics, Inc.
Astellas and the flying star logo are registered trademarks of Astellas Pharma Inc.
Seattle Genetics and the Seattle Genetics logo are registered trademarks of Seattle Genetics, Inc.


© 2020 Astellas Pharma US, Inc. and Seattle Genetics, Inc. All rights reserved. 081-0199-PM 07/20
PADCEV and the PADCEV logo are trademarks jointly owned by Agensys, Inc. and Seattle Genetics, Inc.
Astellas and the flying star logo are registered trademarks of Astellas Pharma Inc.
Seattle Genetics and the Seattle Genetics logo are registered trademarks of Seattle Genetics, Inc.